Endocrine Abstracts

Introduction: Malignant tumors of pituitary are very rare diseases.Case report: We present the case of a 37 years male that progressed in 6 months from normal life to erectile dysfunction and severe panic attacks. The lab panel showed severe insufficiency of testosterone and thyroid hormones. MRI examination revealed a large pituitary tumor, extending to hypothalamus and temporal lobe, also to cavernous sinus. The tumor was treated for 30 days with Caber...

We present three cases of females with low body weight that needed large amounts of anti-thyroid drugs – 4–5 mg/kg Thiamazole and 50 mg/kg of Propylthiouracil. First patient, aged 32, weight 45 kg, had Graves’s disease evolving for more than five years. She has been proposed surgery and needed 1200 mg/day of Propylthiouracil. She delayed surgery for 2 weeks, then the dosage required for euthyroidism was 1800 mg/day for three weeks. The goitre had 1.2 kg, from ma...

Introduction: Insulinomas are the most common cause of hypoglycemia due to endogenous hyperinsulinism. Almost all insulinomas are benign, and long-term recovery with complete disappearance of preoperative symptoms can be expected after complete resection.Case report: A 33-year-old woman, who developed gestational diabetes during her second pregnancy, which persisted post-partum, stopped insulin due to recurrent severe hypoglycemia, but which persisted ev...

We present the case of a 51 years old woman, nonsmoker, without relevant past medical history, who presented with acute psychotic state starting the third day of treatment with prednisone 30 mg indicated for allergy. She had also arterial hypertension and a significant and progressive loss of proximal muscle strength in her legs. The initial evaluation showed hyperglycemia, metabolic alkalosis and severe hypokalemia. Basal plasma cortisol was high (>90 μg/dl) and did ...

Introduction: Paraneoplastic Cushing’ syndrome (CS) represents 5–10% of all CS and has a severe prognosis due to severe metabolic imbalance, denutrition, associated infections, and progression of tumoural underlying pathology.A 67 years old woman presented with mental confusion, progressive weight loss, severe oedema and kypokalaemia, without typical features of Cushing or hyperpigmentation. Investigations revealed paraneoplastic Cushing’s...